Drug interactions
Brigatinib + Pimozide
Severity: Moderate
Brigatinib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4, which could lower pimozide concentrations and reduce its effect. Because pimozide has a narrow therapeutic index, fluctuating exposure complicates control of tics.
What this interaction means in plain words
Brigatinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Possible CYP3A4 induction by brigatinib, which increases pimozide metabolism.
What to do
Monitor clinical response to pimozide and adjust the dose as needed. Consider an alternative if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Pimozide?
MediHelp rates the interaction as moderate. Brigatinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4, which could lower pimozide concentrations and reduce its effect. Because pimozide has a narrow therapeutic index, fluctuating exposure complicates control of tics.
How serious is the interaction between Brigatinib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to pimozide and adjust the dose as needed. Consider an alternative if control is lost.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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