Drug interactions
Brimonidine + Captopril-hydrochlorothiazide
Severity: Minor
Brimonidine and Captopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can lower blood pressure when absorbed systemically, which may add to the effect of captopril and hydrochlorothiazide. With ophthalmic use the systemic exposure is low, so the effect is usually small.
What this interaction means in plain words
Brimonidine and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Captopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism and the antihypertensive agents.
What to do
Monitor blood pressure and watch for dizziness or orthostasis after starting brimonidine, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Brimonidine and Captopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can lower blood pressure when absorbed systemically, which may add to the effect of captopril and hydrochlorothiazide. With ophthalmic use the systemic exposure is low, so the effect is usually small.
How serious is the interaction between Brimonidine and Captopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and watch for dizziness or orthostasis after starting brimonidine, especially in older patients.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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