Drug interactions
Brimonidine + Chlorzoxazone
Severity: Minor
Brimonidine and Chlorzoxazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of ophthalmic brimonidine can cause drowsiness, and chlorzoxazone may add to this effect. The practical impact is usually small with eye drops.
What this interaction means in plain words
Brimonidine and Chlorzoxazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects from systemically absorbed brimonidine, an alpha-2 agonist.
What to do
Counsel patients to watch for unusual drowsiness and avoid driving if affected. No dose changes are normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brimonidine and Chlorzoxazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Chlorzoxazone?
MediHelp rates the interaction as minor. Brimonidine and Chlorzoxazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of ophthalmic brimonidine can cause drowsiness, and chlorzoxazone may add to this effect. The practical impact is usually small with eye drops.
How serious is the interaction between Brimonidine and Chlorzoxazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to watch for unusual drowsiness and avoid driving if affected. No dose changes are normally required.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
