Drug interactions
Brimonidine + Deutetrabenazine
Severity: Moderate
Brimonidine and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine commonly causes somnolence and fatigue, and brimonidine may contribute additional drowsiness. The combination may impair alertness.
What this interaction means in plain words
Brimonidine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive sedation from VMAT2 inhibition-related CNS effects and alpha-2 agonism.
What to do
Monitor for increased sedation and advise caution with driving. Adjust the deutetrabenazine dose if sedation becomes limiting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Deutetrabenazine?
MediHelp rates the interaction as moderate. Brimonidine and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine commonly causes somnolence and fatigue, and brimonidine may contribute additional drowsiness. The combination may impair alertness.
How serious is the interaction between Brimonidine and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and advise caution with driving. Adjust the deutetrabenazine dose if sedation becomes limiting.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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