Drug interactions
Brimonidine + Doxepin
Severity: Moderate
Brimonidine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects. Brimonidine may add to drowsiness; in addition, tricyclics may reduce the effect of alpha-2 agonists on intraocular pressure.
What this interaction means in plain words
Brimonidine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from H1 antagonism and alpha-2 agonism; tricyclics may also antagonize alpha-2 mediated effects.
What to do
Monitor for sedation and for adequacy of intraocular pressure control. Counsel on driving and consider dose adjustment if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Brimonidine with Doxepin?
MediHelp rates the interaction as moderate. Brimonidine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects. Brimonidine may add to drowsiness; in addition, tricyclics may reduce the effect of alpha-2 agonists on intraocular pressure.
How serious is the interaction between Brimonidine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for adequacy of intraocular pressure control. Counsel on driving and consider dose adjustment if drowsiness is excessive.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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