Drug interactions
Brimonidine + Enalapril-hydrochlorothiazide
Severity: Minor
Brimonidine and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can be absorbed systemically after ophthalmic use and may lower blood pressure. Additive hypotension with an ACE inhibitor and thiazide is possible but usually slight.
What this interaction means in plain words
Brimonidine and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from central alpha-2 agonism with ACE inhibition and diuresis.
What to do
Monitor blood pressure if symptoms of dizziness arise after starting brimonidine. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Brimonidine and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can be absorbed systemically after ophthalmic use and may lower blood pressure. Additive hypotension with an ACE inhibitor and thiazide is possible but usually slight.
How serious is the interaction between Brimonidine and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if symptoms of dizziness arise after starting brimonidine. No routine dose change is needed.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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