Drug interactions
Brimonidine + Felodipine
Severity: Minor
Brimonidine and Felodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can lower blood pressure after systemic absorption. An additive hypotensive effect with felodipine is theoretically possible. With eye drops, systemic exposure is minimal.
What this interaction means in plain words
Brimonidine and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Felodipine belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through pharmacodynamic effects.
What to do
No routine change is needed. Ask about dizziness, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Felodipine?
MediHelp rates the interaction as minor. Brimonidine and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can lower blood pressure after systemic absorption. An additive hypotensive effect with felodipine is theoretically possible. With eye drops, systemic exposure is minimal.
How serious is the interaction between Brimonidine and Felodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Ask about dizziness, particularly in older patients.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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