Drug interactions
Brimonidine + Fosinopril-hydrochlorothiazide
Severity: Minor
Brimonidine and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist, and ophthalmic use has minimal systemic absorption, so any additive blood pressure lowering with fosinopril and hydrochlorothiazide is unlikely to be clinically relevant. Occasional systemic hypotension has been reported with brimonidine.
What this interaction means in plain words
Brimonidine and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Potential additive hypotension from alpha-2 agonism, limited by low systemic absorption.
What to do
No specific action is needed. Check blood pressure if the patient reports dizziness after starting brimonidine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Brimonidine and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist, and ophthalmic use has minimal systemic absorption, so any additive blood pressure lowering with fosinopril and hydrochlorothiazide is unlikely to be clinically relevant. Occasional systemic hypotension has been reported with brimonidine.
How serious is the interaction between Brimonidine and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Check blood pressure if the patient reports dizziness after starting brimonidine.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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