Drug interactions
Brimonidine + Metaxalone
Severity: Minor
Brimonidine and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine, particularly when absorbed systemically, can cause drowsiness and fatigue. With metaxalone, sedation may be increased, although ophthalmic use gives limited systemic exposure.
What this interaction means in plain words
Brimonidine and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Metaxalone belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression through alpha-2 agonist effects and metaxalone sedation.
What to do
Usually no change is needed; ask patients about excess drowsiness and advise caution with driving if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Metaxalone?
MediHelp rates the interaction as minor. Brimonidine and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine, particularly when absorbed systemically, can cause drowsiness and fatigue. With metaxalone, sedation may be increased, although ophthalmic use gives limited systemic exposure.
How serious is the interaction between Brimonidine and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; ask patients about excess drowsiness and advise caution with driving if it occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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