Drug interactions
Brimonidine + Methohexital
Severity: Moderate
Brimonidine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression. Systemic brimonidine may potentiate sedation, which matters in perioperative settings.
What this interaction means in plain words
Brimonidine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by the barbiturate and central alpha-2 agonism by brimonidine.
What to do
Inform the anesthesia team of brimonidine use and titrate methohexital to effect with standard respiratory and hemodynamic monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Brimonidine with Methohexital?
MediHelp rates the interaction as moderate. Brimonidine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic that causes marked CNS and respiratory depression. Systemic brimonidine may potentiate sedation, which matters in perioperative settings.
How serious is the interaction between Brimonidine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of brimonidine use and titrate methohexital to effect with standard respiratory and hemodynamic monitoring.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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