Drug interactions
Brimonidine + Nebivolol
Severity: Minor
Brimonidine and Nebivolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist, usually given ophthalmically with small systemic absorption, which may cause some bradycardia or hypotension. Combined with nebivolol the effect on blood pressure and heart rate is usually small.
What this interaction means in plain words
Brimonidine and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Nebivolol belongs to Cardiovascular.
Why it happens
Possible additive hypotensive and bradycardic effects from central alpha-2 agonism and beta-blockade.
What to do
Usually no action is required. Monitor pulse and blood pressure if the patient reports dizziness or fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Nebivolol?
MediHelp rates the interaction as minor. Brimonidine and Nebivolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist, usually given ophthalmically with small systemic absorption, which may cause some bradycardia or hypotension. Combined with nebivolol the effect on blood pressure and heart rate is usually small.
How serious is the interaction between Brimonidine and Nebivolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no action is required. Monitor pulse and blood pressure if the patient reports dizziness or fatigue.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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