Drug interactions
Brimonidine + Sufentanil
Severity: Moderate
Brimonidine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness, and sufentanil is a potent opioid with CNS and respiratory depressant effects. Combined use may deepen sedation, although systemic exposure from ophthalmic brimonidine is low.
What this interaction means in plain words
Brimonidine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brimonidine belongs to Miscellaneous; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from alpha-2 adrenergic agonism and opioid receptor agonism.
What to do
Monitor sedation level and respiratory status when sufentanil is given to patients using brimonidine, and titrate the opioid dose to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Brimonidine with Sufentanil?
MediHelp rates the interaction as moderate. Brimonidine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brimonidine is an alpha-2 agonist that can cause drowsiness, and sufentanil is a potent opioid with CNS and respiratory depressant effects. Combined use may deepen sedation, although systemic exposure from ophthalmic brimonidine is low.
How serious is the interaction between Brimonidine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status when sufentanil is given to patients using brimonidine, and titrate the opioid dose to effect.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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