Drug interactions
Brimonidine + Thioridazine
Severity: Minor
Brimonidine and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is a sedating phenothiazine, and systemically absorbed brimonidine can cause drowsiness and lower blood pressure. Together they may produce additive drowsiness and hypotension. The effect is usually modest with ophthalmic brimonidine.
What this interaction means in plain words
Brimonidine and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression and alpha-adrenergic related hypotension.
What to do
Counsel the patient about drowsiness and orthostatic dizziness, especially after starting either drug or increasing a dose. Reassess if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Thioridazine?
MediHelp rates the interaction as minor. Brimonidine and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thioridazine is a sedating phenothiazine, and systemically absorbed brimonidine can cause drowsiness and lower blood pressure. Together they may produce additive drowsiness and hypotension. The effect is usually modest with ophthalmic brimonidine.
How serious is the interaction between Brimonidine and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and orthostatic dizziness, especially after starting either drug or increasing a dose. Reassess if excessive sedation occurs.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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