Drug interactions
Brimonidine + Tolcapone
Severity: Minor
Brimonidine and Tolcapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone can cause somnolence and dyskinesia-related effects, and brimonidine can cause drowsiness, so some additive sedation is conceivable. The documented basis for a meaningful interaction is weak.
What this interaction means in plain words
Brimonidine and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Tolcapone belongs to Central Nervous System.
Why it happens
Possible additive sedation; no well-established pharmacological mechanism.
What to do
Counsel patients to report excessive daytime sleepiness and avoid driving if drowsy; no dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Brimonidine with Tolcapone?
MediHelp rates the interaction as minor. Brimonidine and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolcapone can cause somnolence and dyskinesia-related effects, and brimonidine can cause drowsiness, so some additive sedation is conceivable. The documented basis for a meaningful interaction is weak.
How serious is the interaction between Brimonidine and Tolcapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report excessive daytime sleepiness and avoid driving if drowsy; no dose change is routinely needed.
What other medicines interact with Brimonidine?
MediHelp also lists interactions of Brimonidine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Brimonidine page.
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