Drug interactions
Brivaracetam + Clobazam
Severity: Moderate
Brivaracetam and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that causes sedation, and brivaracetam commonly causes somnolence and dizziness. Combined use is common in epilepsy but may increase drowsiness and impair coordination.
What this interaction means in plain words
Brivaracetam and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and SV2A-related effects.
What to do
Monitor for sedation, ataxia and falls, particularly at initiation or dose changes. Adjust either dose if adverse effects limit function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Brivaracetam with Clobazam?
MediHelp rates the interaction as moderate. Brivaracetam and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that causes sedation, and brivaracetam commonly causes somnolence and dizziness. Combined use is common in epilepsy but may increase drowsiness and impair coordination.
How serious is the interaction between Brivaracetam and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and falls, particularly at initiation or dose changes. Adjust either dose if adverse effects limit function.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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