Drug interactions
Brivaracetam + Clomipramine
Severity: Moderate
Brivaracetam and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents act on the central nervous system and can cause somnolence, dizziness and fatigue. Used together, these effects may add up and impair alertness. Clomipramine also lowers the seizure threshold, which may counter the anticonvulsant benefit.
What this interaction means in plain words
Brivaracetam and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression; clomipramine also lowers the seizure threshold.
What to do
Monitor seizure control and sedation after starting or changing doses. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Clomipramine?
MediHelp rates the interaction as moderate. Brivaracetam and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents act on the central nervous system and can cause somnolence, dizziness and fatigue. Used together, these effects may add up and impair alertness. Clomipramine also lowers the seizure threshold, which may counter the anticonvulsant benefit.
How serious is the interaction between Brivaracetam and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and sedation after starting or changing doses. Advise caution with driving and machinery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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