Drug interactions
Brivaracetam + Clorazepate
Severity: Moderate
Brivaracetam and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam commonly causes somnolence and dizziness, which may add to the sedation caused by clorazepate. This can impair alertness and coordination, particularly after initiation or dose increases.
What this interaction means in plain words
Brivaracetam and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression through different mechanisms (GABA-A potentiation and SV2A binding).
What to do
Monitor for sedation and dizziness when adding or titrating either drug. Counsel about driving and reduce doses if impairment is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Clorazepate?
MediHelp rates the interaction as moderate. Brivaracetam and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam commonly causes somnolence and dizziness, which may add to the sedation caused by clorazepate. This can impair alertness and coordination, particularly after initiation or dose increases.
How serious is the interaction between Brivaracetam and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness when adding or titrating either drug. Counsel about driving and reduce doses if impairment is significant.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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