Drug interactions
Brivaracetam + Fluphenazine
Severity: Moderate
Brivaracetam and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired coordination, so combined use may increase CNS depression. Antipsychotics may also lower the seizure threshold, which can oppose the anticonvulsant effect.
What this interaction means in plain words
Brivaracetam and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; phenothiazines may lower the seizure threshold.
What to do
Monitor for sedation and for any change in seizure control, and warn patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Fluphenazine?
MediHelp rates the interaction as moderate. Brivaracetam and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and impaired coordination, so combined use may increase CNS depression. Antipsychotics may also lower the seizure threshold, which can oppose the anticonvulsant effect.
How serious is the interaction between Brivaracetam and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any change in seizure control, and warn patients about driving.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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