Drug interactions
Brivaracetam + Hydroxyzine
Severity: Moderate
Brivaracetam and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating and brivaracetam commonly causes somnolence and dizziness. Combined use can increase drowsiness and impair concentration and coordination.
What this interaction means in plain words
Brivaracetam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression from brivaracetam and the sedating antihistamine hydroxyzine.
What to do
Monitor for excessive sedation and counsel patients against driving until the combined effect is known. Reduce the hydroxyzine dose if drowsiness is excessive, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Brivaracetam with Hydroxyzine?
MediHelp rates the interaction as moderate. Brivaracetam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is sedating and brivaracetam commonly causes somnolence and dizziness. Combined use can increase drowsiness and impair concentration and coordination.
How serious is the interaction between Brivaracetam and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel patients against driving until the combined effect is known. Reduce the hydroxyzine dose if drowsiness is excessive, particularly in older patients.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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