Drug interactions
Brivaracetam + Iloperidone
Severity: Moderate
Brivaracetam and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is sedating and can cause orthostatic dizziness, while brivaracetam also causes somnolence and dizziness. Combined use may increase impairment of alertness and risk of falls.
What this interaction means in plain words
Brivaracetam and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from antipsychotic antihistaminic and alpha-blocking effects plus brivaracetam's neurological effects.
What to do
Monitor for sedation and orthostatic symptoms, especially at initiation and dose changes. Counsel patients about driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brivaracetam and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brivaracetam
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Brivaracetam with Iloperidone?
MediHelp rates the interaction as moderate. Brivaracetam and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is sedating and can cause orthostatic dizziness, while brivaracetam also causes somnolence and dizziness. Combined use may increase impairment of alertness and risk of falls.
How serious is the interaction between Brivaracetam and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, especially at initiation and dose changes. Counsel patients about driving and fall risk.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
