Drug interactions
Brivaracetam + Lasmiditan
Severity: Moderate
Brivaracetam and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness, somnolence and other CNS effects, and brivaracetam has similar effects. Taking both may amplify drowsiness and impaired cognition or driving ability.
What this interaction means in plain words
Brivaracetam and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS effects; lasmiditan is a 5-HT1F agonist and brivaracetam binds SV2A.
What to do
Monitor for sedation and dizziness after lasmiditan doses. Advise patients not to drive for at least 8 hours after taking lasmiditan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Brivaracetam with Lasmiditan?
MediHelp rates the interaction as moderate. Brivaracetam and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness, somnolence and other CNS effects, and brivaracetam has similar effects. Taking both may amplify drowsiness and impaired cognition or driving ability.
How serious is the interaction between Brivaracetam and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness after lasmiditan doses. Advise patients not to drive for at least 8 hours after taking lasmiditan.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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