Drug interactions
Brivaracetam + Midazolam
Severity: Moderate
Brivaracetam and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam commonly causes somnolence, dizziness and fatigue. Taken with midazolam, these CNS effects may be additive.
What this interaction means in plain words
Brivaracetam and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression from SV2A-mediated antiepileptic effect and GABA-A potentiation.
What to do
Monitor sedation and coordination when starting or adjusting either drug. Warn patients about impaired driving ability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Midazolam?
MediHelp rates the interaction as moderate. Brivaracetam and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam commonly causes somnolence, dizziness and fatigue. Taken with midazolam, these CNS effects may be additive.
How serious is the interaction between Brivaracetam and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and coordination when starting or adjusting either drug. Warn patients about impaired driving ability.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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