Drug interactions
Brivaracetam + Promethazine
Severity: Moderate
Brivaracetam and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam commonly causes somnolence and dizziness, and promethazine is strongly sedating. Together they can increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Brivaracetam and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excessive sedation and falls, particularly when starting therapy or increasing doses. Counsel patients on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Promethazine?
MediHelp rates the interaction as moderate. Brivaracetam and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brivaracetam commonly causes somnolence and dizziness, and promethazine is strongly sedating. Together they can increase drowsiness and impair alertness and coordination.
How serious is the interaction between Brivaracetam and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, particularly when starting therapy or increasing doses. Counsel patients on driving and machinery.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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