Drug interactions
Brivaracetam + Selinexor
Severity: Moderate
Brivaracetam and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and brivaracetam can cause similar CNS effects. Together the neurological toxicity may be more pronounced, raising the risk of falls and impaired function.
What this interaction means in plain words
Brivaracetam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no pharmacokinetic mechanism established.
What to do
Monitor for dizziness, confusion and somnolence, and advise patients to avoid driving. Reduce the brivaracetam dose or manage selinexor dosing per its labeling if neurological symptoms become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brivaracetam and Selinexor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brivaracetam
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Brivaracetam with Selinexor?
MediHelp rates the interaction as moderate. Brivaracetam and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and brivaracetam can cause similar CNS effects. Together the neurological toxicity may be more pronounced, raising the risk of falls and impaired function.
How serious is the interaction between Brivaracetam and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and somnolence, and advise patients to avoid driving. Reduce the brivaracetam dose or manage selinexor dosing per its labeling if neurological symptoms become troublesome.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
