Drug interactions
Amitriptyline + Selinexor
Severity: Moderate
Amitriptyline and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects. Amitriptyline is sedating and anticholinergic and may add to these effects, raising the risk of falls and cognitive impairment.
What this interaction means in plain words
Amitriptyline and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients about fall risk. Consider reducing the amitriptyline dose or choosing a less sedating agent if neurological effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
- Baclofen + Selinexor Moderate
Frequently asked questions
Can I take Amitriptyline with Selinexor?
MediHelp rates the interaction as moderate. Amitriptyline and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects. Amitriptyline is sedating and anticholinergic and may add to these effects, raising the risk of falls and cognitive impairment.
How serious is the interaction between Amitriptyline and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients about fall risk. Consider reducing the amitriptyline dose or choosing a less sedating agent if neurological effects emerge.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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