Drug interactions
Aripiprazole + Selinexor
Severity: Moderate
Aripiprazole and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological toxicity, and aripiprazole can also cause dizziness, somnolence and impaired cognition. Using them together may increase the burden of CNS effects and the risk of falls.
What this interaction means in plain words
Aripiprazole and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system adverse effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel the patient on fall risk and driving. Reduce or hold doses if neurological symptoms become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Asenapine + Selinexor Moderate
- Baclofen + Selinexor Moderate
Frequently asked questions
Can I take Aripiprazole with Selinexor?
MediHelp rates the interaction as moderate. Aripiprazole and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological toxicity, and aripiprazole can also cause dizziness, somnolence and impaired cognition. Using them together may increase the burden of CNS effects and the risk of falls.
How serious is the interaction between Aripiprazole and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel the patient on fall risk and driving. Reduce or hold doses if neurological symptoms become troublesome.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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