Drug interactions
Amobarbital + Selinexor
Severity: Moderate
Amobarbital and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor can cause neurological effects such as dizziness, confusion and somnolence. Combined with a sedative barbiturate, these effects may be additive and raise the risk of falls and impaired cognition.
What this interaction means in plain words
Amobarbital and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive CNS-depressant and neurotoxic effects; no pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and oversedation, and counsel on fall risk. Reduce or avoid the sedative where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
- Baclofen + Selinexor Moderate
Frequently asked questions
Can I take Amobarbital with Selinexor?
MediHelp rates the interaction as moderate. Amobarbital and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor can cause neurological effects such as dizziness, confusion and somnolence. Combined with a sedative barbiturate, these effects may be additive and raise the risk of falls and impaired cognition.
How serious is the interaction between Amobarbital and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and oversedation, and counsel on fall risk. Reduce or avoid the sedative where alternatives exist.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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