Drug interactions
Brivaracetam + Temazepam
Severity: Moderate
Brivaracetam and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic, and combining it with brivaracetam can increase sedation, dizziness and psychomotor impairment. Falls and next-day impairment are the main concerns, especially in older adults.
What this interaction means in plain words
Brivaracetam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects via GABA-A potentiation and SV2A-mediated effects.
What to do
Use the lowest effective temazepam dose and monitor for sedation and falls. Counsel on driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Brivaracetam with Temazepam?
MediHelp rates the interaction as moderate. Brivaracetam and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic, and combining it with brivaracetam can increase sedation, dizziness and psychomotor impairment. Falls and next-day impairment are the main concerns, especially in older adults.
How serious is the interaction between Brivaracetam and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for sedation and falls. Counsel on driving and alcohol avoidance.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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