Drug interactions
Chloral hydrate + Temazepam
Severity: Major
Chloral hydrate and Temazepam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedative-hypnotics, so combined use can lead to excessive sedation, impaired coordination and respiratory depression. Risk is higher in older adults and those with lung disease.
What this interaction means in plain words
Chloral hydrate and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloral hydrate belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Avoid concurrent hypnotic use if possible; otherwise use the lowest effective doses and monitor sedation and respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Other interactions of Temazepam
Frequently asked questions
Can I take Chloral hydrate with Temazepam?
MediHelp rates the interaction as major. Chloral hydrate and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are sedative-hypnotics, so combined use can lead to excessive sedation, impaired coordination and respiratory depression. Risk is higher in older adults and those with lung disease.
How serious is the interaction between Chloral hydrate and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent hypnotic use if possible; otherwise use the lowest effective doses and monitor sedation and respiratory function.
What other medicines interact with Chloral hydrate?
MediHelp also lists interactions of Chloral hydrate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Chloral hydrate page.
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