Drug interactions
Brodalumab + Phenytoin
Severity: Minor
Brodalumab and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 expression through cytokines, and IL-17 pathway blockade could restore enzyme activity. This could slightly lower concentrations of narrow-therapeutic-index drugs such as phenytoin, though the effect is theoretical and not well documented for brodalumab.
What this interaction means in plain words
Brodalumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brodalumab belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Why it happens
Possible normalization of cytokine-suppressed CYP450 expression after starting brodalumab.
What to do
Check phenytoin levels and seizure control when brodalumab is started or stopped; adjust the phenytoin dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Brodalumab
Frequently asked questions
Can I take Brodalumab with Phenytoin?
MediHelp rates the interaction as minor. Brodalumab and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression through cytokines, and IL-17 pathway blockade could restore enzyme activity. This could slightly lower concentrations of narrow-therapeutic-index drugs such as phenytoin, though the effect is theoretical and not well documented for brodalumab.
How serious is the interaction between Brodalumab and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check phenytoin levels and seizure control when brodalumab is started or stopped; adjust the phenytoin dose if needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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