Drug interactions
Brodalumab + Warfarin
Severity: Moderate
Brodalumab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inflammation in psoriasis can suppress CYP enzyme activity, and treatments that reduce inflammation may restore it. This could change warfarin clearance and alter INR after brodalumab is started or stopped.
What this interaction means in plain words
Brodalumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brodalumab belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Normalization of cytokine-mediated suppression of CYP450 enzymes during IL-17 receptor blockade may alter warfarin metabolism.
What to do
Monitor INR more frequently when brodalumab is started or stopped. Adjust the warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brodalumab
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Brodalumab with Warfarin?
MediHelp rates the interaction as moderate. Brodalumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inflammation in psoriasis can suppress CYP enzyme activity, and treatments that reduce inflammation may restore it. This could change warfarin clearance and alter INR after brodalumab is started or stopped.
How serious is the interaction between Brodalumab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when brodalumab is started or stopped. Adjust the warfarin dose accordingly.
What other medicines interact with Brodalumab?
MediHelp also lists interactions of Brodalumab with, for example, Upadacitinib, Carbamazepine, Clonidine. The full list is on the Brodalumab page.
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