Drug interactions
Brodalumab + Upadacitinib
Severity: Major
Brodalumab and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brodalumab blocks IL-17 signalling, and with upadacitinib there is a possible additive risk of infection. Combined use is not well studied.
What this interaction means in plain words
Brodalumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brodalumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression via IL-17 receptor blockade and JAK inhibition.
What to do
Avoid combining biologic and JAK inhibitor therapy. If unavoidable, monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Other interactions of Brodalumab
Frequently asked questions
Can I take Brodalumab with Upadacitinib?
MediHelp rates the interaction as major. Brodalumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brodalumab blocks IL-17 signalling, and with upadacitinib there is a possible additive risk of infection. Combined use is not well studied.
How serious is the interaction between Brodalumab and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining biologic and JAK inhibitor therapy. If unavoidable, monitor for infection.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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