Drug interactions
Brodalumab + Theophylline
Severity: Minor
Brodalumab and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation raises cytokines that suppress CYP450 enzyme formation. IL-17 receptor blockade with brodalumab may reverse this suppression, so theophylline clearance could rise and serum levels fall. Because theophylline has a narrow therapeutic index, the effect could be clinically relevant at the start or stop of brodalumab.
What this interaction means in plain words
Brodalumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brodalumab belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Reduced cytokine-mediated suppression of CYP1A2 may increase theophylline metabolism.
What to do
Check serum theophylline concentrations and clinical response when brodalumab is started or stopped. Adjust the theophylline dose if levels change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Brodalumab
- Brodalumab + Upadacitinib Major
- Brodalumab + Warfarin Moderate
- Brodalumab + Carbamazepine Minor
- Brodalumab + Clonidine Minor
- Brodalumab + Cyclosporin Minor
- Brodalumab + Phenytoin Minor
Frequently asked questions
Can I take Brodalumab with Theophylline?
MediHelp rates the interaction as minor. Brodalumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation raises cytokines that suppress CYP450 enzyme formation. IL-17 receptor blockade with brodalumab may reverse this suppression, so theophylline clearance could rise and serum levels fall. Because theophylline has a narrow therapeutic index, the effect could be clinically relevant at the start or stop of brodalumab.
How serious is the interaction between Brodalumab and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum theophylline concentrations and clinical response when brodalumab is started or stopped. Adjust the theophylline dose if levels change.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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