Drug interactions
Bromocriptine + Captopril
Severity: Moderate
Bromocriptine and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine can cause orthostatic hypotension, particularly at initiation, and may add to the effect of captopril. Syncope and dizziness are the main concerns.
What this interaction means in plain words
Bromocriptine and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Captopril belongs to Cardiovascular.
Why it happens
Additive hypotension from dopamine agonist effects on vascular tone and sympathetic outflow with ACE inhibition.
What to do
Start bromocriptine at a low dose and monitor blood pressure, particularly in the first days. Adjust captopril if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Captopril?
MediHelp rates the interaction as moderate. Bromocriptine and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine can cause orthostatic hypotension, particularly at initiation, and may add to the effect of captopril. Syncope and dizziness are the main concerns.
How serious is the interaction between Bromocriptine and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start bromocriptine at a low dose and monitor blood pressure, particularly in the first days. Adjust captopril if hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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