Drug interactions
Bromocriptine + Cobicistat
Severity: Major
Bromocriptine and Cobicistat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and may considerably raise bromocriptine exposure. This can cause nausea, hypotension, syncope and other dopaminergic effects, and ergot-related toxicity is a concern with potent CYP3A4 inhibitors.
What this interaction means in plain words
Bromocriptine and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Cobicistat belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism by cobicistat.
What to do
Start with a low bromocriptine dose and titrate carefully, or choose an alternative dopamine agonist. Monitor blood pressure and for signs of ergot toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bromocriptine
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Bromocriptine with Cobicistat?
MediHelp rates the interaction as major. Bromocriptine and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and may considerably raise bromocriptine exposure. This can cause nausea, hypotension, syncope and other dopaminergic effects, and ergot-related toxicity is a concern with potent CYP3A4 inhibitors.
How serious is the interaction between Bromocriptine and Cobicistat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low bromocriptine dose and titrate carefully, or choose an alternative dopamine agonist. Monitor blood pressure and for signs of ergot toxicity.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Darunavir. The full list is on the Bromocriptine page.
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