Drug interactions
Amisulpride + Bromocriptine
Severity: Major
Amisulpride and Bromocriptine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride is a selective D2/D3 receptor antagonist and opposes the dopaminergic action of bromocriptine. This can reduce control of Parkinson disease or hyperprolactinemia, and the agonist may in turn worsen psychosis.
What this interaction means in plain words
Amisulpride and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Bromocriptine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2/D3 receptors.
What to do
Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, and monitor symptoms and prolactin if both must be used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bromocriptine
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Bromocriptine?
MediHelp rates the interaction as major. Amisulpride and Bromocriptine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride is a selective D2/D3 receptor antagonist and opposes the dopaminergic action of bromocriptine. This can reduce control of Parkinson disease or hyperprolactinemia, and the agonist may in turn worsen psychosis.
How serious is the interaction between Amisulpride and Bromocriptine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, and monitor symptoms and prolactin if both must be used.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Bromocriptine page.
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