Drug interactions
Bromocriptine + Dihydroergotamine
Severity: Major
Bromocriptine and Dihydroergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are ergot derivatives with vasoconstrictive activity, so combined use may add to the risk of ergotism, including hypertension, peripheral ischemia and vasospasm. Dihydroergotamine also has serotonergic and adrenergic effects that add to bromocriptine's vascular effects.
What this interaction means in plain words
Bromocriptine and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic vasoconstrictive and ergot-related effects at vascular receptors.
What to do
Avoid concurrent use; choose a non-ergot alternative for migraine or for the dopamine agonist indication. If unavoidable, monitor for ischemic symptoms and blood pressure elevation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bromocriptine
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Bromocriptine with Dihydroergotamine?
MediHelp rates the interaction as major. Bromocriptine and Dihydroergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are ergot derivatives with vasoconstrictive activity, so combined use may add to the risk of ergotism, including hypertension, peripheral ischemia and vasospasm. Dihydroergotamine also has serotonergic and adrenergic effects that add to bromocriptine's vascular effects.
How serious is the interaction between Bromocriptine and Dihydroergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-ergot alternative for migraine or for the dopamine agonist indication. If unavoidable, monitor for ischemic symptoms and blood pressure elevation.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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