Drug interactions
Bromocriptine + Carbidopa-entacapone-levodopa
Severity: Moderate
Bromocriptine and Carbidopa-entacapone-levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is a dopamine agonist that adds to levodopa's dopaminergic effect, which can be useful in Parkinson disease. Together they may increase dyskinesia, nausea, orthostatic hypotension, hallucinations and impulse control problems.
What this interaction means in plain words
Bromocriptine and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Carbidopa-entacapone-levodopa belongs to Central Nervous System.
Why it happens
Additive dopaminergic receptor stimulation.
What to do
Titrate both drugs slowly and consider lowering the levodopa dose as bromocriptine is increased. Monitor for dyskinesia, hypotension and psychiatric effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as moderate. Bromocriptine and Carbidopa-entacapone-levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine is a dopamine agonist that adds to levodopa's dopaminergic effect, which can be useful in Parkinson disease. Together they may increase dyskinesia, nausea, orthostatic hypotension, hallucinations and impulse control problems.
How serious is the interaction between Bromocriptine and Carbidopa-entacapone-levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs slowly and consider lowering the levodopa dose as bromocriptine is increased. Monitor for dyskinesia, hypotension and psychiatric effects.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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