Drug interactions
Bromocriptine + Conivaptan
Severity: Moderate
Bromocriptine and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may increase bromocriptine concentrations. This raises the risk of hypotension, nausea and other dopaminergic effects, although conivaptan is given only briefly.
What this interaction means in plain words
Bromocriptine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing bromocriptine clearance.
What to do
Monitor blood pressure and bromocriptine adverse effects during conivaptan infusion. Consider holding or reducing the bromocriptine dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Conivaptan?
MediHelp rates the interaction as moderate. Bromocriptine and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may increase bromocriptine concentrations. This raises the risk of hypotension, nausea and other dopaminergic effects, although conivaptan is given only briefly.
How serious is the interaction between Bromocriptine and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and bromocriptine adverse effects during conivaptan infusion. Consider holding or reducing the bromocriptine dose if symptoms occur.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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