Drug interactions
Bromocriptine + Dabrafenib
Severity: Moderate
Bromocriptine and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib is a CYP3A4 inducer and may reduce bromocriptine concentrations. Reduced effectiveness of bromocriptine could result.
What this interaction means in plain words
Bromocriptine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, accelerating bromocriptine metabolism.
What to do
Monitor the therapeutic response to bromocriptine, such as prolactin or motor control. Titrate the bromocriptine dose upward if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Dabrafenib
Frequently asked questions
Can I take Bromocriptine with Dabrafenib?
MediHelp rates the interaction as moderate. Bromocriptine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib is a CYP3A4 inducer and may reduce bromocriptine concentrations. Reduced effectiveness of bromocriptine could result.
How serious is the interaction between Bromocriptine and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the therapeutic response to bromocriptine, such as prolactin or motor control. Titrate the bromocriptine dose upward if needed.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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