Drug interactions
Bromocriptine + Danazol
Severity: Moderate
Bromocriptine and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may increase bromocriptine exposure. This may lead to hypotension, nausea, headache and other dopaminergic adverse effects.
What this interaction means in plain words
Bromocriptine and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4-mediated metabolism of bromocriptine.
What to do
Monitor blood pressure and adverse effects, and reduce the bromocriptine dose if toxicity develops. Titrate cautiously when starting or stopping danazol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Danazol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Danazol?
MediHelp rates the interaction as moderate. Bromocriptine and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may increase bromocriptine exposure. This may lead to hypotension, nausea, headache and other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects, and reduce the bromocriptine dose if toxicity develops. Titrate cautiously when starting or stopping danazol.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
