Drug interactions
Bromocriptine + Droperidol
Severity: Moderate
Bromocriptine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol blocks dopamine D2 receptors and so opposes the effect of bromocriptine. This can reduce bromocriptine efficacy, for example worsening parkinsonism or hyperprolactinemia control.
What this interaction means in plain words
Bromocriptine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: D2 receptor blockade by droperidol versus D2 agonism by bromocriptine.
What to do
Use a non-dopamine-blocking antiemetic such as ondansetron where possible (mind QT risk) and monitor for loss of bromocriptine effect. Single perioperative doses are generally manageable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Droperidol?
MediHelp rates the interaction as moderate. Bromocriptine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol blocks dopamine D2 receptors and so opposes the effect of bromocriptine. This can reduce bromocriptine efficacy, for example worsening parkinsonism or hyperprolactinemia control.
How serious is the interaction between Bromocriptine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-dopamine-blocking antiemetic such as ondansetron where possible (mind QT risk) and monitor for loss of bromocriptine effect. Single perioperative doses are generally manageable.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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