Drug interactions
Bromocriptine + Epinephrine
Severity: Moderate
Bromocriptine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise blood pressure, and ergot-type vasoconstriction from bromocriptine may add to the pressor and arrhythmic effects of epinephrine. Hypertension and tachyarrhythmias are possible, particularly with systemic or large-dose epinephrine.
What this interaction means in plain words
Bromocriptine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Why it happens
Additive pharmacodynamic effects: sympathomimetic vasoconstriction and cardiac stimulation combined with the vasoactive effects of bromocriptine.
What to do
Monitor blood pressure and heart rhythm when epinephrine is given systemically to a patient on bromocriptine. Titrate epinephrine to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Bromocriptine with Epinephrine?
MediHelp rates the interaction as moderate. Bromocriptine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise blood pressure, and ergot-type vasoconstriction from bromocriptine may add to the pressor and arrhythmic effects of epinephrine. Hypertension and tachyarrhythmias are possible, particularly with systemic or large-dose epinephrine.
How serious is the interaction between Bromocriptine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm when epinephrine is given systemically to a patient on bromocriptine. Titrate epinephrine to the lowest effective dose.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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