Drug interactions
Bromocriptine + Nitroglycerin sublingual
Severity: Minor
Bromocriptine and Nitroglycerin sublingual: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual nitroglycerin is used for acute angina, and bromocriptine can cause vasoconstriction, orthostatic hypotension and rarely coronary vasospasm. Any antagonism is theoretical and weak, and the pair is not a recognized contraindication. Additive hypotension is the more practical concern.
What this interaction means in plain words
Bromocriptine and Nitroglycerin sublingual have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical opposing vascular effects and possible additive hypotension; not well established.
What to do
No empirical dose change is needed. Counsel patients to sit when taking nitroglycerin and monitor blood pressure after bromocriptine initiation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Nitroglycerin sublingual?
MediHelp rates the interaction as minor. Bromocriptine and Nitroglycerin sublingual have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sublingual nitroglycerin is used for acute angina, and bromocriptine can cause vasoconstriction, orthostatic hypotension and rarely coronary vasospasm. Any antagonism is theoretical and weak, and the pair is not a recognized contraindication. Additive hypotension is the more practical concern.
How serious is the interaction between Bromocriptine and Nitroglycerin sublingual?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Counsel patients to sit when taking nitroglycerin and monitor blood pressure after bromocriptine initiation.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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