Drug interactions
Bromocriptine + Octreotide
Severity: Moderate
Bromocriptine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatostatin analogues such as octreotide may reduce the clearance of CYP450 substrates, and octreotide has been reported to raise bromocriptine bioavailability. This could increase dopaminergic adverse effects such as nausea and hypotension.
What this interaction means in plain words
Bromocriptine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Octreotide may reduce hepatic metabolic clearance of bromocriptine, a CYP3A4 substrate.
What to do
Monitor for increased bromocriptine adverse effects and reduce the dose if they occur. Check growth hormone and prolactin response when used together in acromegaly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Octreotide
Frequently asked questions
Can I take Bromocriptine with Octreotide?
MediHelp rates the interaction as moderate. Bromocriptine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatostatin analogues such as octreotide may reduce the clearance of CYP450 substrates, and octreotide has been reported to raise bromocriptine bioavailability. This could increase dopaminergic adverse effects such as nausea and hypotension.
How serious is the interaction between Bromocriptine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased bromocriptine adverse effects and reduce the dose if they occur. Check growth hormone and prolactin response when used together in acromegaly.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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