Drug interactions
Bromocriptine + Olanzapine / samidorphan
Severity: Moderate
Bromocriptine and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine blocks dopamine D2 receptors and opposes the effects of bromocriptine, which may reduce its efficacy. Dopamine agonists may also worsen psychotic symptoms.
What this interaction means in plain words
Bromocriptine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor for loss of bromocriptine effect and for psychiatric symptoms; consider an alternative if the indication for bromocriptine is Parkinson disease or prolactinoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Bromocriptine and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine blocks dopamine D2 receptors and opposes the effects of bromocriptine, which may reduce its efficacy. Dopamine agonists may also worsen psychotic symptoms.
How serious is the interaction between Bromocriptine and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bromocriptine effect and for psychiatric symptoms; consider an alternative if the indication for bromocriptine is Parkinson disease or prolactinoma.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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