Drug interactions
Bromocriptine + Olanzapine
Severity: Moderate
Bromocriptine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine blocks dopamine receptors and opposes the effect of bromocriptine, a dopamine agonist. This can reduce control of Parkinson disease or hyperprolactinaemia and may worsen motor or psychotic symptoms.
What this interaction means in plain words
Bromocriptine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade and D2 agonism.
What to do
Avoid in Parkinson disease where possible and use quetiapine or clozapine if an antipsychotic is required. Monitor motor symptoms or prolactin and adjust therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Olanzapine?
MediHelp rates the interaction as moderate. Bromocriptine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine blocks dopamine receptors and opposes the effect of bromocriptine, a dopamine agonist. This can reduce control of Parkinson disease or hyperprolactinaemia and may worsen motor or psychotic symptoms.
How serious is the interaction between Bromocriptine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson disease where possible and use quetiapine or clozapine if an antipsychotic is required. Monitor motor symptoms or prolactin and adjust therapy.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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