Drug interactions
Bromocriptine + Pimozide
Severity: Moderate
Bromocriptine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide blocks D2 receptors and opposes the dopamine agonist action of bromocriptine. This can reduce its effect in Parkinson disease or hyperprolactinemia.
What this interaction means in plain words
Bromocriptine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors; pimozide also raises prolactin.
What to do
Avoid using the two together where possible. If both are needed, monitor symptom control or prolactin levels and consider an alternative antipsychotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Pimozide?
MediHelp rates the interaction as moderate. Bromocriptine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide blocks D2 receptors and opposes the dopamine agonist action of bromocriptine. This can reduce its effect in Parkinson disease or hyperprolactinemia.
How serious is the interaction between Bromocriptine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together where possible. If both are needed, monitor symptom control or prolactin levels and consider an alternative antipsychotic.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
