Drug interactions
Bromocriptine + Rifampin
Severity: Moderate
Bromocriptine and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong CYP3A4 inducer and is expected to markedly lower bromocriptine concentrations. Loss of efficacy may occur in hyperprolactinemia, acromegaly or Parkinson disease.
What this interaction means in plain words
Bromocriptine and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4 and intestinal metabolism, increasing bromocriptine clearance.
What to do
Monitor prolactin or clinical response and increase the bromocriptine dose as needed during rifampin therapy. Reduce the dose after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Rifampin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Rifampin?
MediHelp rates the interaction as moderate. Bromocriptine and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong CYP3A4 inducer and is expected to markedly lower bromocriptine concentrations. Loss of efficacy may occur in hyperprolactinemia, acromegaly or Parkinson disease.
How serious is the interaction between Bromocriptine and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prolactin or clinical response and increase the bromocriptine dose as needed during rifampin therapy. Reduce the dose after rifampin is stopped.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
