Drug interactions
Bromocriptine + Trifluoperazine
Severity: Moderate
Bromocriptine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine is a phenothiazine antipsychotic with D2 antagonism that opposes bromocriptine's dopaminergic effect. This may reduce efficacy and increase prolactin.
What this interaction means in plain words
Bromocriptine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor for loss of bromocriptine efficacy such as prolactin level and symptom control; consider an alternative antipsychotic with low D2 blockade if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Trifluoperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Trifluoperazine?
MediHelp rates the interaction as moderate. Bromocriptine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine is a phenothiazine antipsychotic with D2 antagonism that opposes bromocriptine's dopaminergic effect. This may reduce efficacy and increase prolactin.
How serious is the interaction between Bromocriptine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bromocriptine efficacy such as prolactin level and symptom control; consider an alternative antipsychotic with low D2 blockade if feasible.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
